Yes! The Nul Programme is based on The Sinclair Method, which is backed by over 90 clinical trials and has a 78% success rate¹ in reducing alcohol use. It has been studied for decades and is recognized as an evidence-based approach to alcohol reduction.

Before you start, ensure you have:
✔ Your prescribed medication
✔ A drink log or journal (we’ll be launching an app for this soon!)
✔ Remedies for potential side effects (e.g., light snacks, anti-nausea medication)

--> Take your medication 1–2 hours before drinking.
--> If you are not drinking that day, do not take the medication.
--> Always wait at least one hour before consuming alcohol after taking the pill.

--> Before drinking? Take it as soon as you remember and wait at least one hour before drinking.
--> After drinking has started? Take it as soon as possible, but note that the extinction effect may be weaker. Never skip your dose entirely.

Yes! Many people find that taking your medication with food helps minimize nausea. You can also take it with an anti-nausea medication if needed.

Many people report that alcohol feels "muted" or less rewarding after taking the medication. The usual "buzz" is often weaker, and over time, your cravings for alcohol should diminish.

Keeping a drink log or journal is one of the most effective ways to monitor your progress. Note the following after each drinking session:
--> Number of drinks consumed
--> Timing and setting
--> Mood, cravings, and any side effects
--> Small wins (e.g., choosing a non-alcoholic drink, feeling less urge to drink)

The Nul Programme is a gradual process. Some people notice changes within weeks, while others take several months to see significant reductions in cravings. Patience and consistency are key!

--> Pause and assess: Ask yourself why you want a drink.
--> Use the HALT method: Are you Hungry, Angry, Lonely, or Tired? Address these needs first.
--> Delay the decision: If you still want to drink, set a timer for 15–30 minutes before deciding.
--> Engage in an alternative activity: Try exercise, journaling, or connecting with a friend.

--> Change your routine: If you always drink in the same place at the same time, mix it up.
--> Drink mindfully: Pour smaller amounts, sip slowly, and pause before refilling.
--> Avoid common triggers: Identify and reduce exposure to people, places, or situations that encourage drinking.

Use the SMART goal framework:
✔ Specific: "I’ll reduce my drinking by one drink per week."
✔ Measurable: Use your log to track progress.
✔ Achievable: Set goals that are realistic.
✔ Relevant: Align with your personal motivation for change.
✔ Timeline-Based: Check in with yourself every 30 days.

If you’re drinking at an all-day event (like a wedding or holiday), a second dose may be needed 4–8 hours after the first. Always consult your doctor about second dosing.

Most side effects are mild and temporary, including:
--> Nausea (take with food to help)
--> Headache
--> Dizziness
--> Fatigue or difficulty sleeping

‍If side effects persist or worsen, consult your clinician.

People who:
-> Are pregnant, breastfeeding, or trying to become pregnant.
-> Are under 18 years of age.
-> Use opioid medications and/or substances and are unable or unwilling to stop.
-> Have pancreatic, liver or kidney problems.
-> Are allergic to the medications or their ingredients.
-> Are dependent on alcohol and experience physical withdrawal symptoms.
-> Require alcohol detoxification.
-> In addition to these, some groups, including those with significant mental health considerations, will be assessed on a case by case basis

You may notice signs of extinction, such as:
✔ Drinking less frequently or consuming smaller amounts
✔ Forgetting to drink or leaving drinks unfinished
✔ Feeling indifferent toward alcohol

✔ Keep a drink log
✔ Join the Nul community for support
✔ Check in with a clinician as standard once a month (email hello@choosenul.com to schedule)
✔ Set personal goals and adjust as needed

We offer guided therapy support with trained IFS (Internal Family Systems) therapists to complement your journey with The Nul Programme. Contact hello@choosenul.com for details.

-> It’s important for every healthcare professional, including your GP, to have a complete understanding of any medications you are taking or have taken in the past. 
-> With your consent, the clinician will write to your GP to inform them about the medication prescribed for you. This is so that they can update your primary health record, which is relied upon by many healthcare professionals, including emergency healthcare professionals.
-> If you don’t want your GP to be contacted, the prescriber will discuss this with you to understand your reasoning. They’ll then use this rationale to determine whether or not it is safe to prescribe you the medication without letting your GP know. This decision is solely at their discretion and they may determine that they cannot prescribe to you in this instance.

Our healthcare partner is Blueco Healthcare, a CQC registered online doctor service. Medicines are delivered by Pharmalogic Chemist. For more information, registration numbers, and contact details, click here.

Yes, you need a prescription for nalmefene and naltrexone as they are prescription only medicines (POMs). This is so that a clinician can oversee your treatment, be there for you to reach out to between prescriptions, and to ensure that the medication will be safe and effective for you.

-> Once we have all of your information (including your LFTs), your order will be reviewed within one working day. When your order leaves the pharmacy, you will receive an email from the carrier advising you of the expected delivery date as well as a link to track your parcel. 
-> Your medication will be shipped via Royal Mail Tracked 24 & Signed For, which is typically a next-day service. However, in some cases and certain areas, delivery may take up to two days.

To ensure medicines are delivered to you safely and securely, you must sign for your parcel when it is delivered.

-> On the day of despatch and on the day of delivery, you should receive an email and/or SMS from the carrier. This will let you know when you can expect your order and it will also provide you with tracking details. 
-> If you are expecting an order and haven’t received it - and/or the tracking looks wrong - you can contact us at hello@choosenul.com.

If your order is damaged, lost, or you’ve received incorrect items, please contact us at hello@choosenul.com.

If you need an extra prescription sooner due to travel, losing your medication, or using more than anticipated, contact us at hello@choosenul.com. Depending on the nature of your request, you may need to speak with a clinician to authorise this.